Article

CrisPam: SNP-derived PAM analysis web tool and human pathogenic SNPs database for CRISPR allele-specific targeting

2019-04-30

Abstract excerpt

<h4>Background: </h4> CRISPR is a promising novel technology for treating genetic conditions. Therefore, it is essential to further develop and promote treatment’s safety and specificity. While the guide-RNA offers position-specific DNA targeting, it may tolerate small changes such as single-nucleotide polymorphisms (SNPs). To that end, an allele-specific targeting approach is in need for future treatments of hete...

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Literature Corpus work: fa1678ee-bc34-5fc6-a7f9-adb96387f9f4
DOI: 10.21203/rs.2.9413/v1

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