Article

APOL1 Monoallelic and Biallelic genotypes and CKD, Proteinuria and FSGS in African Americans from the Vanderbilt Biobank (BioVU)

2025-11-13

Abstract excerpt

<h4>Background</h4> African Americans are at increased risk for chronic kidney disease (CKD) in part due to Apolipoprotein L1 gene (APOL1) high-risk genotypes. Recently, a study from West Africa reported an association between monoallelic genotypes and risk of CKD and focal segmental glomerulosclerosis (FSGS). We here study the association of biallelic and monoallelic genotypes with CKD, proteinuria, and FSGS in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16f57adc-27c2-5fd3-9d0e-ce24116682a3
DOI: 10.1101/2025.11.05.25339478

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

APOL1 Monoallelic and Biallelic genotypes and CKD, Proteinuria and FSGS in African Americans from the Vanderbilt Biobank (BioVU)DOI 10.1101/2025.11.05.25339478Read

APOL1 Bi- and Monoallelic Variants and Chronic Kidney Disease in West AfricansSemantic proximity Read

APOL1 variants associate with increased risk of CKD among African Americans.Semantic proximity Read

Apolipoprotein L1 High-Risk Genotypes and Albuminuria in Sub-Saharan African Populations.Semantic proximity Read

Apolipoprotein L1 (APOL1) and Nephropathy.Semantic proximity Read

APOL1 and kidney diseaseSemantic proximity Read

Phenome-wide analysis reveals epistatic associations between APOL1 variants and chronic kidney disease and multiple other disorders.Semantic proximity Read

Multi-ethnic polygenic risk modifies the association between <i>APOL1</i> high risk genotypes and chronic kidney diseaseSemantic proximity Read

KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans.Semantic proximity Read

KidneyGenAfrica: A multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 continental and diasporan AfricansSemantic proximity Read

APOL1 Kidney Risk Variants and Proteomics.Semantic proximity Read

Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease.Semantic proximity Read

Population-based risk assessment of APOL1 on renal disease.Semantic proximity Read