Article

Neuroprotective tissue adaptation induced by IL-12 attenuates CNS inflammation

2022-09-16

Abstract excerpt

IL-12 is a well-established driver of type 1 immune responses. Paradoxically, in several autoimmune conditions including neuroinflammation, IL-12 reduces pathology and exhibits regulatory properties. Yet, the mechanism and the involved cellular players behind this immune regulation remain elusive. To identify the IL-12-responsive elements which prevent immunopathology, we generated mouse models lacking a functiona...

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Literature Corpus work: 16e578b6-fa84-555e-93e3-ca9cacce7a3e
DOI: 10.1101/2022.09.14.506749

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