Oncogenic NFE2L2 mutations in plasma ctDNA and tumors are predictors and prognosticators of chemoradiation therapy in resectable esophageal squamous cell carcinoma.

doi:10.1038/s41416-025-03113-2

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Oncogenic NFE2L2 mutations in plasma ctDNA and tumors are predictors and prognosticators of chemoradiation therapy in resectable esophageal squamous cell carcinoma.

British journal of cancer - 1 Oct 2025

Ko Josephine Mun-Yee, Guo Chen, Leung Alvin Ka-Kiu, Chan Steve Chun-Yin, Lo Anthony Wing-Ip, Tao Lihua, Ng Hoi-Yan, Wong Carissa Wing-Yan, Law Simon, Wong Ian Yu-Hong, Wong Claudia Lai-Yin, Chan Fion Siu-Yin, Chan Kwan Kit, Law Tsz Ting, Lam Ka-On, Kwong Dora Lai-Wan, Dai Wei, Lam Alfred King-Yin, Lung Maria Li

Abstract excerpt

BACKGROUND: The poor prognosis of resectable esophageal squamous cell carcinoma (ESCC) poses an unmet need to identify early predictive and prognostic genomic biomarkers to improve treatment outcome and risk stratification. METHODS: Mutational profiling was performed for 171 ESCC patients receiving curative neoadjuvant chemoradiation treatment (nCRT). The discovery cohort included 100 ESCC formalin-fixed...

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Identifiers

PMID: 40781161
DOI: 10.1038/s41416-025-03113-2
PMCID: PMC12480664

Genes

NFE2L2
KEAP1

Provenance

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