Article

CCmed: cross-condition mediation analysis for identifying robust trans-eQTLs and assessing their effects on human traits

2019-10-13

Abstract excerpt

Trans-eQTLs collectively explain a substantial proportion of expression variation, yet are challenging to detect and replicate since their effects are individually weak. Many trans-effects are mediated by cis-gene expression and some of those effects are shared across tissue types/conditions. To detect robust cis-mediated trans-associations at the gene-level and for specific single nucleotide polymorphisms (SNPs),...

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Literature Corpus work: 1c277dbc-05a0-5065-96e2-4641d3c7ae55
DOI: 10.1101/803106

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