Article

Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration

2020-07-16

Abstract excerpt

Age-related macular degeneration (AMD) damages the retinal pigment epithelium (RPE), the tissue that safeguards photoreceptor health, leading to irreversible vision loss. Polymorphisms in cholesterol and complement genes are implicated in AMD, yet mechanisms linking risk variants to RPE injury remain unclear. We sought to determine how allelic variants in the apolipoprotein E cholesterol transporter modulate RPE h...

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Literature Corpus work: 16b0df62-d3a9-5678-aca0-2132bf84658b
DOI: 10.1101/2020.07.15.201723

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