Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity

3 Aug 2022

Abstract excerpt

Age-related macular degeneration (AMD), the leading cause of blindness among the elderly, is without treatment for early disease. Degenerative retinal pigment epithelial (RPE) cell heterogeneity is a well-recognized but understudied pathogenic factor. Due to the daily phagocytosis of photoreceptor outer segments, unique photo-oxidative stress, and high metabolism for maintaining vision, the RPE has robust...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35921555
DOI: 10.1080/15548627.2022.2109286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneityPMID 35921555Read ↗

Role of Mitochondria in Retinal Pigment Epithelial Aging and DegenerationSemantic proximity Read ↗

Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina.Semantic proximity Read ↗

Pathway-selective mitophagy regulates retinal physiology and neurogenic transitions in Muller gliaSemantic proximity Read ↗

Autophagy in age-related macular degenerationSemantic proximity Read ↗

Mitophagy: An Emerging Target in Ocular PathologySemantic proximity Read ↗

Mitochondrial Dysfunction and Mitophagy in Fuchs Endothelial Corneal DystrophySemantic proximity Read ↗

Mitophagy in the retina: Viewing mitochondrial homeostasis through a new lensSemantic proximity Read ↗

Mitochondrial quality control in AMD: does mitophagy play a pivotal role?Semantic proximity Read ↗

Pathological mitophagy disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy.Semantic proximity Read ↗

Prominin-1 Regulates Retinal Pigment Epithelium Homeostasis: Transcriptomic Insights into Degenerative MechanismsSemantic proximity Read ↗

High resolution imaging and interpretation of three-dimensional RPE sheet structureSemantic proximity Read ↗

Comprehensive transcriptomic analysis reveals canonical and novel pathways modulated by nanoceria in mammalian retinal degenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.