Article

Acid sphingomyelinase inhibition restores RPE homeostasis and photoreceptor function in preclinical Stargardt macular degeneration models

2026-02-22

Abstract excerpt

<h4>ABSTRACT</h4> Stargardt disease, which destroys central high-resolution vision in over 2 million people globally, lacks effective therapies. The primary site of damage in Stargardt disease is the retinal pigment epithelium (RPE), which safeguards photoreceptor health and function. Progressive loss of RPE integrity precedes visual deficits, yet insight into mechanisms driving RPE dysfunction and how this influ...

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Literature Corpus work: 6f00730e-9067-5fd1-8c7a-02a05c4725a3
DOI: 10.64898/2026.02.20.706984

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