Article
Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina.
Journal of extracellular vesicles - 1 Dec 2022
Kurzawa-Akanbi Marzena, Whitfield Phillip, Burté Florence, Bertelli Pietro Maria, Pathak Varun, Doherty Mary, Hilgen Birthe, Gliaudelytė Lina, Platt Mark, Queen Rachel, Coxhead Jonathan, Porter Andrew, Öberg Maria, Fabrikova Daniela, Davey Tracey, Beh Chia Shyan, Georgiou Maria, Collin Joseph, Boczonadi Veronika, Härtlova Anetta, Taggart Michael, Al-Aama Jumana, Korolchuk Viktor I, Morris Christopher M, Guduric-Fuchs Jasenka, Steel David H, Medina Reinhold J, Armstrong Lyle, Lako Majlinda
Abstract excerpt
Age-related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal and choroidal angiogenesis. Here we use AMD patient-specific RPE cells with the Complement Factor H Y402H high-risk polymorphism to perform a comprehensive analysis of extracellular vesicles (EVs), their cargo and role in disease pathology....
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