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Article

The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality.

Pharmaceutical research - 1 Oct 2021

Kiander Wilma, Vellonen Kati-Sisko, Malinen Melina M, Gynther Mikko, Hagström Marja, Bhattacharya Madhushree, Auriola Seppo, Koenderink Jan B, Kidron Heidi

Abstract excerpt

PURPOSE: Organic Anion Transporting Polypeptide 1B1 (OATP1B1) mediates hepatic influx and clearance of many drugs, including statins. The SLCO1B1 gene is highly polymorphic and its function-impairing variants can predispose patients to adverse effects. The effects of rare genetic variants of SLCO1B1 are mainly unexplored. We examined the impact of eight naturally occurring rare variants and the well-known SLCO1B1...

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Biological Transport
Drug Interactions
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Isoquinolines
Liver-Specific Organic Anion Transporter 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rosuvastatin Calcium

Tandem Mass Spectrometry

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Identifiers

PMID: 34647232
DOI: 10.1007/s11095-021-03107-8
PMCID: PMC8602229

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