Article

A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8

2022-10-04

Abstract excerpt

Small animal models have been a challenge for the study of SARS-CoV-2 transmission, with most investigators using golden hamsters or ferrets 1, 2 . Mice have the advantages of low cost, wide availability, less regulatory and husbandry challenges, and the existence of a versatile reagent and genetic toolbox. However, adult mice do not robustly transmit SARS-CoV-2 3 . Here we establish a model based on neonatal mi...

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Literature Corpus work: 4f17ce04-1c59-5af1-a56f-9ef65e7178ec
DOI: 10.1101/2022.10.04.510658

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