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Genome-wide association, Mendelian Randomization and polygenic risk score studies converge on a role of β−amyloid and <i>APOE</i> locus in Parkinson disease

2020-07-03

Abstract excerpt

Alpha-Synuclein (α-Syn) is the main protein component of Lewy bodies (LB), the pathological hallmark of Parkinson’s disease (PD). Cerebrospinal fluid (CSF) levels of α-Syn are not currently used as a clinical biomarker but may be a proxy for pathological α-Syn accumulation in the brain. Therefore, identifying genetic modifiers of CSF α-Syn levels could provide insights into the underlying molecular mechanisms lead...

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Literature Corpus work
161e3f46-25ef-5d51-849d-7e7f4a8cb74c
DOI
10.1101/2020.07.01.20144493
Open publication

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Genome-wide association, Mendelian Randomization and polygenic risk score studies converge on a role of β−amyloid and <i>APOE</i> locus in Parkinson diseaseDOI 10.1101/2020.07.01.20144493
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