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Article

Lysosomal polygenic risk is associated with the severity of neuropathology in Lewy body disease

29 May 2023

Abstract excerpt

Intraneuronal accumulation of misfolded α-synuclein is the pathological hallmark of Parkinson's disease and dementia with Lewy bodies, often co-occurring with variable degrees of Alzheimer's disease related neuropathology. Genetic association studies have successfully identified common variants associated with disease risk and phenotypic traits in Lewy body disease, yet little is known about the genetic...

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PMID: 37247383
DOI: 10.1093/brain/awad183

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