Article

Polyphenols Suppress Intracellular Zinc Deficiency–Induced ROS Production and NLRP3 Inflammasome Activation in Microglia and Neuronal Cells

2026-05-14

Abstract excerpt

Zinc deficiency is increasingly recognized as a risk factor for neurodegenerative diseases, yet the underlying molecular mechanisms remain incompletely understood. In this study, we investigated the impact of intracellular zinc depletion on oxidative stress and in-flammasome activation in microglial (SIM-A9) and neuronal (SH-SY5Y) cell models, and evaluated the protective effects of polyphenolic compounds. Intrace...

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Literature Corpus work: 16183222-4afd-57fe-bc04-05dd40a75471
DOI: 10.20944/preprints202605.0922.v1

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