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Zinc Deficiency Induces Autophagy in HT-22 Mouse Hippocampal Neuronal Cell Line

8 Aug 2022

Abstract excerpt

Zinc is a trace metal vital for various functions in nerve cells, although the effect of zinc deficiency on neuronal autophagy remains unclear. This study aimed to elucidate whether zinc deficiency induced by treatment with N, N, N', N'-tetrakis (2-pyridylmethyl) ethylenediamine (TPEN), a zinc chelator, affects and alters autophagy activity. In cell viability assays, TPEN showed cytotoxicity in HT-22 cells. TPEN...

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PMID: 35955944
DOI: 10.3390/ijms23158811

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