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Glia and zinc in ageing and Alzheimerâ€™s disease: a mechanism for cognitive decline?

25 Jun 2014

Abstract excerpt

Normal ageing is characterized by cognitive decline across a range of neurological functions, which are further impaired in Alzheimer's disease (AD). Recently, alterations in zinc (Zn) concentrations, particularly at the synapse, have emerged as a potential mechanism underlying the cognitive changes that occur in both ageing and AD. Zn is now accepted as a potent neuromodulator, affecting a variety of signaling...

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PMID: 25009495
DOI: 10.3389/fnagi.2014.00137

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