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Article

Zinc Overload Enhances APP Cleavage and Aβ Deposition in the Alzheimer Mouse Brain

17 Dec 2010

Abstract excerpt

BACKGROUND: Abnormal zinc homeostasis is involved in β-amyloid (Aβ) plaque formation and, therefore, the zinc load is a contributing factor in Alzheimer's disease (AD). However, the involvement of zinc in amyloid precursor protein (APP) processing and Aβ deposition has not been well established in AD animal models in vivo. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, APP and presenilin 1 (PS1) double...

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PMID: 21179415
DOI: 10.1371/journal.pone.0015349

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