Article
Dopamine transporter: basic science and human variation of a key molecule for dopaminergic function, locomotion, and parkinsonism.
Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2003
Uhl George R
Abstract excerpt
We review the basic science of the dopamine transporter (DAT), a key neurotransmitter for locomotor control and reward systems, including those lost or deranged in Parkinson's disease (PD). Physiology, pharmaceutical features, expression, cDNA, protein structure/function relationships, and phosphorylation and regulation are discussed. The localization of DAT provides the best marker for the integrity of just the...
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