Article

Age-induced midbrain-striatum assembloids model early phenotypes of Parkinson’s disease

2023-11-01

Abstract excerpt

Parkinson’s disease (PD), one of the most common aging-associated neurodegenerative disorders, is characterised by nigrostriatal pathway dysfunction, caused by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) of the midbrain and the dopamine depletion in the striatum. State of the art, human in vitro models are enabling the study of the dopaminergic neurons’ loss, but not the...

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Literature Corpus work: c928417c-b3d2-561b-ab21-6f32bd0745a7
DOI: 10.1101/2023.10.28.564305

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