Article

Endometriosis lesions are oligoclonal structures derived from the normal endometrium

2026-02-26

Abstract excerpt

Endometriosis is characterized by the presence of endometrium-like tissue outside the uterus. The origin of this ectopic tissue is debated, with leading theories including retrograde menstruation and embryonic remnants. Using somatic mutations as markers, we show that endometriosis lesions consist of unrelated clones of epithelial cells, with stromal cells being distinct, and that lesions at different body sites h...

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Literature Corpus work: 16054cf0-835c-58e8-ac4e-756626d9b3f0
DOI: 10.64898/2026.02.25.708037

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