New Lessons about Endometriosis — Somatic Mutations and Disease Heterogeneity

Abstract excerpt

Endometriosis is a common estrogen-dependent inflammatory disorder that affects 6 to 10% of women of reproductive age and up to 50% of women with infertility and pelvic pain.1 Endometriosis is a complex disease with risk influenced by many factors; its pathogenesis is poorly understood, and current treatments have limitations.2 A role for genetics is well established, with approximately 50% of risk due to genetic...