Article
Cancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology.
Human reproduction update - 15 Apr 2020
Guo Sun-Wei
Abstract excerpt
BACKGROUND: Endometriosis is a benign gynaecological disease. Thus, it came as a complete surprise when it was reported recently that the majority of deep endometriosis lesions harbour somatic mutations and a sizeable portion of them contain known cancer-associated mutations (CAMs). Four more studies have since been published, all demonstrating the existence of CAMs in different subtypes of endometriosis. While...
Topics
- Bone Marrow Cells
- Endometriosis
- Endometrium
- Epithelial Cells
- Epithelial-Mesenchymal Transition
- Female
- Humans
- Mutation
- Neoplasms
- Ovarian Diseases
- Tumor Microenvironment