Article
Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium.
Cell reports - 14 Aug 2018
Suda Kazuaki, Nakaoka Hirofumi, Yoshihara Kosuke, Ishiguro Tatsuya, Tamura Ryo, Mori Yutaro, Yamawaki Kaoru, Adachi Sosuke, Takahashi Tomoko, Kase Hiroaki, Tanaka Kenichi, Yamamoto Tadashi, Motoyama Teiichi, Inoue Ituro, Enomoto Takayuki
Abstract excerpt
Endometriosis is characterized by ectopic endometrial-like epithelium and stroma, of which molecular characteristics remain to be fully elucidated. We sequenced 107 ovarian endometriotic and 82 normal uterine endometrial epithelium samples isolated by laser microdissection. In both endometriotic and normal epithelium samples, numerous somatic mutations were identified within genes frequently mutated in...
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