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Article

Somatic mutations in endometrial epithelium: biological insights and emerging in vitro models.

Molecular human reproduction - 11 Apr 2026

Subramaniam Sugarniya, Gargett Caroline E, Fitzgerald Harriet C, Montgomery Grant W, McKinnon Brett

Abstract excerpt

The human endometrium is a complex, dynamic, and poorly understood tissue involving monthly cyclical regeneration likely from adult stem/progenitor cells. This regeneration is associated with reproductive pathologies, such as endometriosis and adenomyosis. Endometrial epithelial cells have rates of mutations that are higher than expected for non-malignant tissue. Many of these mutations occur in known...

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Identifiers

PMID: 42105224
DOI: 10.1093/molehr/gaag027
PMCID: PMC13275306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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