Back to search

Article

Single Nucleus RNA Sequencing of Human Pancreatic Islets <i>In Vitro</i> and <i>In Vivo</i> Identifies New Gene Sets and Three β-Cell Subpopulations with Different Transcriptional Profile

2022-05-23

Abstract excerpt

Single-cell RNA sequencing (scRNA-seq) has provided valuable insights into human islet cell types and their corresponding stable gene expression profiles. However, this approach requires cell dissociation that complicates its utility in vivo and provides limited information on the active transcriptional status of islet cells. On the other hand, single-nucleus RNA sequencing (snRNA-seq) does not require cell disso...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d7629700-c73c-5ac4-8e7d-665d8d258d18
DOI
10.1101/2022.05.22.492974
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single Nucleus RNA Sequencing of Human Pancreatic Islets <i>In Vitro</i> and <i>In Vivo</i> Identifies New Gene Sets and Three β-Cell Subpopulations with Different Transcriptional ProfileDOI 10.1101/2022.05.22.492974
Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profilesSemantic proximity
Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic isletsSemantic proximity
Human Pancreatic α-Cell Heterogeneity and Trajectory Inference Analysis Using Integrated Single Cell- and Single Nucleus-RNA Sequencing PlatformsSemantic proximity
Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesisSemantic proximity
Lessons from single-cell RNA sequencing of human isletsSemantic proximity
Single-Cell Multi-Omic Roadmap of Human Fetal Pancreatic DevelopmentSemantic proximity
Single-cell RNA-seq transcriptomic landscape of human and mouse islets and pathological alterations of diabetesSemantic proximity
Endocrine Pancreas Development and Dysfunction Through the Lens of Single-Cell RNA-SequencingSemantic proximity
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specificationSemantic proximity
PanKbase Integrated Single-Cell Map: A Comprehensive Atlas of Human Pancreatic IsletsSemantic proximity
Single-Nucleus and In Situ RNA–Sequencing Reveal Cell Topographies in the Human PancreasSemantic proximity
Integrated meta-analysis of public human pancreatic single-cell transcriptomes reveals distinct beta-cell state trajectories across aging and diabetesSemantic proximity
Select a neighboring publication to make it the new centre.