Article

Identification of protein aggregates in the aging vertebrate brain with prion-like and phase separation properties

2022-03-01

Abstract excerpt

<h4>SUMMARY</h4> Protein aggregation, which can sometimes spread in a prion-like manner, is a hallmark of neurodegenerative diseases. However, whether prion-like aggregates form during normal brain aging remains unknown. Here we use quantitative proteomics in the African turquoise killifish to identify protein aggregates that accumulate in old vertebrate brains. These aggregates are enriched for prion-like RNA bi...

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Literature Corpus work: 15dda76e-c796-5e4f-8d1d-4bfafa1d0936
DOI: 10.1101/2022.02.26.482115

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