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Article

hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation.

Cell reports - 28 Jan 2020

Batlle Cristina, Yang Peiguo, Coughlin Maura, Messing James, Pesarrodona Mireia, Szulc Elzbieta, Salvatella Xavier, Kim Hong Joo, Taylor J Paul, Ventura Salvador

Abstract excerpt

Prion-like proteins form multivalent assemblies and phase separate into membraneless organelles. Heterogeneous ribonucleoprotein D-like (hnRNPDL) is a RNA-processing prion-like protein with three alternative splicing (AS) isoforms, which lack none, one, or both of its two disordered domains. It has been suggested that AS might regulate the assembly properties of RNA-processing proteins by controlling the...

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Identifiers

PMID: 31995753
DOI: 10.1016/j.celrep.2019.12.080
PMCID: PMC6996132

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