Article

TYK2 as a novel therapeutic target in Alzheimer’s Disease with TDP-43 inclusions

2024-06-06

Abstract excerpt

<h4>SUMMARY</h4> Neuroinflammation is a pathological feature of many neurodegenerative diseases, including Alzheimer’s disease (AD) 1,2 and amyotrophic lateral sclerosis (ALS) 3 , raising the possibility of common therapeutic targets. We previously established that cytoplasmic double-stranded RNA (cdsRNA) is spatially coincident with cytoplasmic pTDP-43 inclusions in neurons of patients with C9ORF72-mediated AL...

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Literature Corpus work: 45100f23-12ea-5ad8-b66a-bfe26152de90
DOI: 10.1101/2024.06.04.595773

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