Article

Sporadic amyotrophic lateral sclerosis: integral model of pathogenesis and therapy options

2022-08-08

Abstract excerpt

<title>Abstract</title> <p>Amyotrophic lateral sclerosis (ALS) is a rapidly progressive central nervous system degenerative disease, in most cases within 2–3 years inevitably leading to mixed tetraplegia and subsequent death from diaphragmatic paralysis. While for almost half of hereditary cases, mutations are identified as the cause of the disease, the sporadic form of ALS (sALS), due to the polymorphism and com...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7ccd48b0-62b4-5c34-b676-eb031bd1c071
DOI: 10.21203/rs.3.rs-1643391/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sporadic amyotrophic lateral sclerosis: integral model of pathogenesis and therapy optionsDOI 10.21203/rs.3.rs-1643391/v2Read

Advances and challenges in understanding the multifaceted pathogenesis of amyotrophic lateral sclerosis.Semantic proximity Read

Current Understanding of ALS Onset, Progression and TreatmentsSemantic proximity Read

Amyotrophic Lateral Sclerosis: New Insights into Underlying Molecular Mechanisms and Opportunities for Therapeutic InterventionSemantic proximity Read

Amyotrophic Lateral Sclerosis: Advances in Diagnosis, Pathophysiology, and Emerging Therapeutic StrategiesSemantic proximity Read

Molecular mechanisms of amyotrophic lateral sclerosis as broad therapeutic targets for gene therapy applications utilizing adeno‐associated viral vectorsSemantic proximity Read

Pathogenesis of amyotrophic lateral sclerosis.Semantic proximity Read

Amyotrophic lateral sclerosis.Semantic proximity Read

Amyotrophic Lateral Sclerosis and Other Motor Neuron DiseasesSemantic proximity Read

State of the art and the dark side of amyotrophic lateral sclerosisSemantic proximity Read

Progressive speech impairment as the first manifestation of amyotrophic lateral sclerosis: Case report and literature reviewSemantic proximity Read

Amyotrophic lateral sclerosis: recent advances in understanding disease mechanisms.Semantic proximity Read

Unraveling the multifaceted insights into amyotrophic lateral sclerosis: Genetic underpinnings, pathogenesis, and therapeutic horizons.Semantic proximity Read