Article

DHCR7 as a novel regulator of ferroptosis in hepatocytes

2022-06-15

Abstract excerpt

Recent evidence indicates that ferroptosis is implicated in the pathophysiology of various liver diseases; however, the mechanism of ferroptosis regulation in the liver is poorly understood. Here, using the whole-genome screening approach, we identified 7-dehydrocholesterol reductase (DHCR7), the terminal enzyme of cholesterol biosynthesis, as a novel regulator of ferroptosis in hepatocytes. Genetic and pharmacolo...

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Literature Corpus work: 15c6185c-0205-5cc8-86a1-75a1a01aafe5
DOI: 10.1101/2022.06.15.496212

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