A pan-cancer analysis of the oncogenic role of 7-dehydrocholesterol reductase (DHCR7) in human tumors

Abstract excerpt

<h4>Background: </h4> DHCR7, a switch between cholesterol and vitamin D synthesis that plays a pivotal role in tumorigenesis, is a promising therapeutic target in oncology. Despite increasing strong support for its importance, there is no pan-cancer analysis across multiple databases that can be available for in-depth data mining of the gene. <h4>Methods: </h4>: We first investigated the potential oncogenic roles...

Topics

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• Biomarkers, Tumor
• Gene Expression Regulation, Neoplastic
• Microsatellite Instability
• Mutation
• Neoplasms
• Oxidoreductases Acting on CH-CH Group Donors
• Prognosis
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

4092762b-28ed-54c7-a30e-31665e0fef68

DOI

10.21203/rs.3.rs-1797700/v1