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Article

Cannabidiol Is a Potential Inhibitor of Ferroptosis in Human Articular Chondrocytes

27 Jun 2025

Abstract excerpt

The present study investigates the effects of cannabidiol (CBD), the major non-psychoactive compound of Cannabis sativa L. extracts, on ferroptotic cell death in human articular chondrocytes. Exposure to known ferroptosis inducers RSL3, erastin and its analogue IKE, FINO2 and FIN56 led to a varying extent of reduced cell viability in two chondrocyte cell lines (in C-28/I2, T/C-28/A2) and primary chondrocytes,...

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PMID: 40576283
DOI: 10.1111/jcmm.70592

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