Article

CYP2E1 overexpression protects COS-7 cancer cells against ferroptosis

2023-03-22

Abstract excerpt

Ferroptosis is a recently described form of regulated cell death initiated by the iron-mediated one-electron reduction of lipid hydroperoxides (LOOH). Cytochrome P450 2E1 (CYP2E1) induction, a consequence of genetic polymorphisms or/and gene induction by xenobiotics, may promote ferroptosis by contributing to the cellular pool of LOOH. However, CYP2E1 induction also increases the transcription of anti-ferroptotic...

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Literature Corpus work: 1d90e066-f77e-5519-bee0-33b9173a04a4
DOI: 10.21203/rs.3.rs-2702878/v1

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