Article

<i>Bona fide</i> cytotoxic iNKT cells with superior antitumour responses identified in mice and humans

2024-07-22

Abstract excerpt

<h4>SUMMARY</h4> Adoptive cell therapies (ACT) using unmodified or engineered invariant Natural Killer T (iNKT) cells are in clinical trials for cancer treatment. While promising, outcomes are still suboptimal, possibly due to iNKT cell heterogeneity. This study identified unique iNKT cell populations with strong cytotoxic activity in mice and humans. In mice, iNKT1c cells showed potent CD1d-dependent and -indepe...

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Literature Corpus work: 15a6abc1-bccb-5bb9-91fc-89fe05f7bbcf
DOI: 10.1101/2024.07.18.603987

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