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Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

15 Sept 2020

Abstract excerpt

Abstract The functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of current successful cancer immunotherapies. Immune-checkpoint inhibitors are designed to target immune-inhibitory receptors that function to regulate the...

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PMID: 32929195
DOI: 10.1038/s41416-020-01048-4

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