Article
Distinct and overlapping effector functions of expanded human CD4+, CD8α+ and CD4-CD8α- invariant natural killer T cells.
PloS one - 1 Jan 2011
O'Reilly Vincent, Zeng Shijuan G, Bricard Gabriel, Atzberger Ann, Hogan Andrew E, Jackson John, Feighery Conleth, Porcelli Steven A, Doherty Derek G
Abstract excerpt
CD1d-restricted invariant natural killer T (iNKT) cells have diverse immune stimulatory/regulatory activities through their ability to release cytokines and to kill or transactivate other cells. Activation of iNKT cells can protect against multiple diseases in mice but clinical trials in humans have had limited impact. Clinical studies to date have targeted polyclonal mixtures of iNKT cells and we proposed that...
Topics
- Animals
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Membrane
- Cell Proliferation
- Cytokines
- Cytotoxicity, Immunologic
- HeLa Cells
- Humans
- Mice