Article

Metabolic maintenance of breast cancer cells and metastases through E-cadherin/YAP–dependent pyruvate carboxylase expression

2026-04-16

Abstract excerpt

Epithelial-mesenchymal transition (EMT) and glycolytic metabolism are well-characterized drivers of cancer progression and metastasis. However, most primary breast tumors and metastases express E-cadherin and the epithelial phenotype is associated with mitochondrial oxidative metabolism, yet the causality and relevance of these relationships and their underlying mechanisms remain poorly understood. Using a 3D cult...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 158fe853-98a1-5b6f-a30c-884c663463ca
DOI: 10.64898/2026.04.13.718309

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metabolic maintenance of breast cancer cells and metastases through E-cadherin/YAP–dependent pyruvate carboxylase expressionDOI 10.64898/2026.04.13.718309Read

Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancerSemantic proximity Read

PELP1/SRC-3-dependent regulation of metabolic kinases drives therapy resistant ER+ breast cancerSemantic proximity Read

Metabolic reprogramming in breast cancer results in distinct mitochondrial bioenergetics between luminal and basal subtypesSemantic proximity Read

Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survivalSemantic proximity Read

The Flick of a Switch: Conferring Survival Advantage to Breast Cancer Stem Cells Through Metabolic PlasticitySemantic proximity Read

Redox signaling regulates breast cancer metastasis via HIF1α-stimulated EMT dynamics and metabolic reprogrammingSemantic proximity Read

Dynamic links between mechanical forces and metabolism shape the tumor milieu.Semantic proximity Read

Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function.Semantic proximity Read

The Use of Patient-Derived Organoids in the Study of Molecular Metabolic Adaptation in Breast CancerSemantic proximity Read

Integrated Metabolic Complex Genetic Interaction Network of Chromosome 4p Loss in Basal Breast CancerSemantic proximity Read

P-cadherin mechanoactivates tumor–mesothelium metabolic coupling to promote ovarian cancer metastasisSemantic proximity Read

YAP1-TEAD1-Glut1 axis dictates the oncogenic phenotypes of breast cancer cells by modulating glycolysis.Semantic proximity Read