Article

P-cadherin mechanoactivates tumor–mesothelium metabolic coupling to promote ovarian cancer metastasis

2024-06-03

Abstract excerpt

Peritoneal metastasis exacerbates the prognosis of ovarian cancer patients. Adhesion of cancer cells to mesothelium is a rate-limiting prerequisite for this process. How metastatic cells sense and respond to the dynamic biomechanical microenvironment at the mesothelial niche to initiate metastatic lesions remains unclear. Here, the study demonstrates that highly metastatic (HM), but not non-metastatic (NM) ovarian...

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Identifiers and source

Literature Corpus work: aa609ef7-afbe-51ea-ad94-1165a71006ea
DOI: 10.1101/2024.06.02.597059

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