Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival

12 May 2015

Abstract excerpt

Metabolic reprogramming in cancer enhances macromolecule biosynthesis and supports cell survival. Oncogenic drivers affect metabolism by altering distinct metabolic processes and render cancer cells sensitive to perturbations of the metabolic network. This study aimed to identify selective metabolic dependencies in breast cancer by investigating 17 breast cancer cells lines representative of the genetic diversity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Cancer, Hypoxia, and Metabolism
Share to Metabolism, Diabetes, and Cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25965974
DOI: 10.1002/path.4562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survivalPMID 25965974Read ↗

Role of Human Monocarboxylate Transporter 1 (hMCT1) and 4 (hMCT4) in Tumor Cells and the Tumor MicroenvironmentSemantic proximity Read ↗

In Vitro and In Vivo Characterization of MCT1 Inhibitor AZD3965 Confirms Preclinical Safety Compatible with Breast Cancer TreatmentSemantic proximity Read ↗

Bulk and single-cell transcriptome profiling reveal the metabolic heterogeneity in human breast cancersSemantic proximity Read ↗

CircPVT1 weakens miR-33a-5p unleashing the c-MYC/GLS1 metabolic axis in breast cancerSemantic proximity Read ↗

Exploring the role of metabolic pathways in TNBC immunotherapy: insights from single-cell and spatial transcriptomicsSemantic proximity Read ↗

The Use of Patient-Derived Organoids in the Study of Molecular Metabolic Adaptation in Breast CancerSemantic proximity Read ↗

Integrated Metabolic Complex Genetic Interaction Network of Chromosome 4p Loss in Basal Breast CancerSemantic proximity Read ↗

Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function.Semantic proximity Read ↗

Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibitionSemantic proximity Read ↗

Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of ResistanceSemantic proximity Read ↗

The Tissue Expression of MCT3, MCT8, and MCT9 Genes in Women with Breast CancerSemantic proximity Read ↗

YAP1-TEAD1-Glut1 axis dictates the oncogenic phenotypes of breast cancer cells by modulating glycolysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.