Article

MIP3α-Rel <sub>Mtb</sub> intranasal DNA vaccination induces reactive T-cell infiltration into the lungs in mice and macaques

2024-09-08

Abstract excerpt

<h4>ABSTRACT</h4> Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the leading cause of mortality due to a single infectious organism. While generally curable, TB requires a lengthy and complex antibiotic regimen, due in large part to bacteria that can shift to a persistent state in the presence of antibiotic pressure. Rel Mtb is the primary enzyme regulating the stringent response,...

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Literature Corpus work: aa49bde7-b119-5d8a-a93d-f0ee5740d982
DOI: 10.1101/2024.09.04.611263

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