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A refined low-dose murine model of <i>Mycobacterium ulcerans</i> infection to assess integrated immune networks in Buruli ulcer pathogenesis

2025-04-24

Abstract excerpt

Mycobacterium ulcerans , the causative agent of Buruli ulcer, is a slow-growing zoonotic pathogen with distinctive pathogenesis linked primarily to its toxin mycolactone. Recent research has shown that the M. ulcerans infectious dose is very low (<10 colony forming units [CFU]). Buruli ulcer animal infection models traditionally use bacterial challenge doses in the range 10 4 – 10 6 CFU; a range orders of magni...

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Literature Corpus work
29ad2cdb-3c32-5037-85e5-e5b37dafb9b2
DOI
10.1101/2025.04.23.650345
Open publication

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