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Article

Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans

5 Apr 2012

Abstract excerpt

UNLABELLED: Osteopontin (OPN) is an important component of the extracellular matrix (ECM), which promotes liver fibrosis and has been described as a biomarker for its severity. Previously, we have demonstrated that Sex-determining region Y-box 9 (SOX9) is ectopically expressed during activation of hepatic stellate cells (HSC) when it is responsible for the production of type 1 collagen, which causes scar...

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PMID: 22488688
DOI: 10.1002/hep.25758

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