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Stat3 is a mediator for TGFβ1 regulating bromodomain protein 4 and cross-talks with Smad3 signaling and Egr-1 in hepatic stellate cell

2022-10-20

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<title>Abstract</title> <p>Background Bromodomain protein 4 (BrD4), an epigenetic reader, functions as a global genomic regulator to direct hepatic stellate cell (HSC) activation and liver fibrogenesis. Our recent researches demonstrated the effect of TGFβ1, a pivotal pro-fibrotic cytokine, on BrD4 expression through Smad3/Egr1 axis in HSCs. Stat3 is widely acknowledged as a regulator of gene transcription and i...

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Literature Corpus work
7bfe6508-dac7-5c99-9a83-b28836c4d328
DOI
10.21203/rs.3.rs-2138327/v1
Open publication

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Stat3 is a mediator for TGFβ1 regulating bromodomain protein 4 and cross-talks with Smad3 signaling and Egr-1 in hepatic stellate cellDOI 10.21203/rs.3.rs-2138327/v1
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