Article

A Glycosylation-Dependent Checkpoint Restrains Intestinal Intra-Epithelial Lymphocyte Activation

2026-01-02

Abstract excerpt

Intraepithelial lymphocytes (IELs) are abundant in the intestinal epithelium, where they maintain barrier integrity and provide immune defense. Because of their potent cytotoxic and effector potential, IEL activity must be tightly controlled to prevent tissue damage. However, the mechanisms that calibrate IEL responsiveness remain unclear. Here, we identify glucosaminyl (N-acetyl) transferase 2 ( Gcnt2 ) as a key...

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Literature Corpus work: 9d31d3b6-325e-5880-9c18-ce6836bc49f1
DOI: 10.64898/2026.01.02.697332

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