Article

The <i>cis</i> -regulatory effects of modern human-specific variants

2020-10-08

Abstract excerpt

The Neanderthal and Denisovan genomes enabled the discovery of sequences that differ between modern and archaic humans, the majority of which are noncoding. However, our understanding of the regulatory consequences of these differences remains limited, in part due to the decay of regulatory marks in ancient samples. Here, we used a massively parallel reporter assay in embryonic stem cells, neural progenitor cells...

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Literature Corpus work: 14e80ccd-8b28-5706-b5ce-da9df60ea5fc
DOI: 10.1101/2020.10.07.330761

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