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Article

The cis-regulatory effects of modern human-specific variants.

eLife - 22 Apr 2021

Weiss Carly V, Harshman Lana, Inoue Fumitaka, Fraser Hunter B, Petrov Dmitri A, Ahituv Nadav, Gokhman David

Abstract excerpt

The Neanderthal and Denisovan genomes enabled the discovery of sequences that differ between modern and archaic humans, the majority of which are noncoding. However, our understanding of the regulatory consequences of these differences remains limited, in part due to the decay of regulatory marks in ancient samples. Here, we used a massively parallel reporter assay in embryonic stem cells, neural progenitor...

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Identifiers

PMID: 33885362
DOI: 10.7554/eLife.63713
PMCID: PMC8062137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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