Article

Neh1 and Neh3 domains of nuclear factor erythroid 2-related factor 2 mediate its binding to NAD-dependent protein deacetylase sirtuin-6

2022-04-22

Abstract excerpt

Oxidative stress is one of the causes of aging and other diseases. Nrf2 is the main transcription factor regulating antioxidant gene expression. In recent years, it has been found that inhibiting Nrf2 activity or increasing oxidative pressure can replicate premature aging defects, and reactivating Nrf2 activity can reverse nuclear aging defects and restore cell vitality. SIRT6 is one of the few proteins that can r...

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Literature Corpus work: 14c5d1de-fdff-5680-bf84-61cdbdcfd9ce
DOI: 10.21203/rs.3.rs-1552407/v1

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