Article
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage.
Nature cell biology - 1 Sept 2006
Wang Chuangui, Chen Lihong, Hou Xinghua, Li Zhenyu, Kabra Neha, Ma Yihong, Nemoto Shino, Finkel Toren, Gu Wei, Cress W Douglas, Chen Jiandong
Abstract excerpt
The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase Sir2 (silent information regulator 2) regulates gene silencing in yeast and promotes lifespan extension during caloric restriction. The mammalian homologue of Sir2 (SirT1) regulates p53, NF-kappaB and Forkhead transcription factors, and is implicated in stress response. This report shows that the cell-cycle and apoptosis regulator E2F1 induces...
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