Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170

12 Jun 2019

Abstract excerpt

SIRT6 is critical for activating transcription of Nuclear factor (erythroid-derived 2)-like 2 (NRF2) responsive genes during oxidative stress. However, while the mechanism of SIRT6-mediated silencing is well understood, the mechanism of SIRT6-mediated transcriptional activation is unknown. Here, we employed SIRT6 separation of function mutants to reveal that SIRT6 mono-ADP-ribosylation activity is required for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genomics, phytochemicals, and oxidative stress
Share to RNA regulation and disease
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31216030
DOI: 10.1093/nar/gkz528

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170PMID 31216030Read ↗

Emerging roles of SIRT6 in human diseases and its modulatorsSemantic proximity Read ↗

Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signalingSemantic proximity Read ↗

SIRT6, a Mammalian Deacylase with Multitasking AbilitiesSemantic proximity Read ↗

Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repairSemantic proximity Read ↗

Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulatorsSemantic proximity Read ↗

Functional dissection of SIRT6: Identification of domains that regulate histone deacetylase activity and chromatin localizationSemantic proximity Read ↗

The Two-Faced Role of SIRT6 in CancerSemantic proximity Read ↗

Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and miceSemantic proximity Read ↗

Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stressSemantic proximity Read ↗

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2Semantic proximity Read ↗

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA BreaksSemantic proximity Read ↗

DNA stimulates SIRT6 to mono-ADP-ribosylate proteins within histidine repeatsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.