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The Role of NAD+ Dependent Histone Deacetylases (sirtuins) in Ageing

1 Nov 2006

Abstract excerpt

Histone deacetylases (HDACs) are enzymes that are able to deacetylate lysine side chains in histones and certain non-histone proteins which leads to altered states of conformation and activity for the proteins in question. Three classes of histone deacetylases have been recognized in humans. Class I and II are zinc-dependent amidohydrolases and eleven subtypes have been discovered (HDAC1-11). Class III enzymes...

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PMID: 17100594
DOI: 10.2174/1389450110607011553

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